Facile synthesis and in vivo hypoglycemic activity of novel 2, 4- hiazolidinedione derivatives

A series of novel 2, 4-thiazolidinedione derivatives 2-{4-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl] phenoxy}N-(substituted phenyl) acetamides d (1-12) have been accomplished in good yields by stirring 2,4-thiazolidinedione a and 2-(4-formyl phenoxy) N-substituted acetamide c (1-12) at room temperature. Some of the reaction sequences were carried under microwave irradiation which resulted in increased reaction rate and yield enhancement. The synthesized compounds were evaluated for their hypoglycemic activity in Wister albino mice animal model and histopathological studies for kidney and Liver were performed. Some of the derivatives have exhibited promising hypoglycemic activity.